Clinic test
Inherited Iron Overload Risk Test
Checks the three HFE gene variants — C282Y, H63D and S65C — behind hereditary haemochromatosis, the inherited tendency to absorb and store too much iron.
Everything you need to know about Inherited Iron Overload Risk Test
Hereditary haemochromatosis is one of the most common genetic conditions in people of Northern European descent, and one of the most under-diagnosed. In women it often stays hidden for longer: monthly blood loss keeps iron in check until the menopause, after which iron can build up quickly and the early symptoms — tiredness, joint pain, low mood — are easy to put down to other things. Left unchecked, excess iron can damage the liver, heart, pancreas and joints.
This test looks at the three HFE variants responsible for most cases. Knowing you carry two copies (or one of the higher-risk combinations) means your iron can be monitored with simple blood tests and, if it rises, managed very effectively. A genetic test looks at the DNA you were born with. It tells you about inherited likelihood, not certainty: a variant can raise your risk without meaning you will develop the condition, and a clear result does not remove the everyday risk everyone carries. Results are explained to you by our clinical team, and we will say when a conversation with your GP or a genetics service is the right next step.
What's included
3 genes in this test
Worth considering if
- A parent or sibling diagnosed with haemochromatosis
- Persistently raised ferritin or transferrin saturation on previous blood tests
- Unexplained tiredness, joint pain or liver changes, particularly after the menopause
- Northern European or Irish heritage with a family history of liver or heart problems
Your visit
Book online
Add this test — and any others — to your booking, pick a time at the clinic and pay online. No preparation needed.
Your visit
About 15 minutes at 44 Crawford Street, Marylebone. Our clinical team takes your sample (blood sample for dna analysis) and answers any questions.
Results explained
The laboratory analyses your sample and your results are released to your secure account with a written explanation from our clinical team — and a call where something needs talking through.
Inherited Iron Overload Risk Test — FAQs
What do the three variants mean?
Does a positive result mean I have iron overload?
I already know my ferritin is high — should I still do this?
Should my family be tested?
Where is the test done?
How long does the appointment take?
Can I book several tests at once?
How do I pay, and can I cancel?
How do I get my results?
Often booked together
Add several tests to one booking — they are all taken in the same visit.
